Mayo Clinic Diet vs Profile by Sanford: Prices, Programs & Reviews (2026)
Side-by-side comparison updated for 2026. ClearScores, pricing, medications, and ratings compared.
Quick Verdict
Mayo Clinic Diet has the higher ClearScore (78 vs 76)
Mayo Clinic Diet is more affordable ($50/mo vs $279/mo)
Mayo Clinic Diet has higher ratings (4.4/5 vs 4.3/5)
Profile by Sanford scores better on value (3.9/5 vs 3.8/5)
Mayo Clinic Diet
$50/mo
starting price
World-renowned Mayo Clinic's evidence-based weight loss program now includes GLP-1 prescribing with specialized meal plans for medication users.
Profile by Sanford
$279/mo
starting price
Backed by Sanford Health system. Physician-designed GLP-1 programs with nutrition coaching and meal planning at clinics across the Midwest.
Mayo Clinic Diet vs Profile by Sanford: Full Comparison
| Mayo Clinic Diet | Profile by Sanford | |
|---|---|---|
| ClearScore | 78/100 ✓ | 76/100 |
| Overall Rating | 4.4/5 ✓ | 4.3/5 |
| Review Count | 98 | 157 ✓ |
| Starting Price | $50/mo ✓ | $279/mo |
| Medications | Branded Semaglutide, Branded Tirzepatide, Branded Liraglutide ✓ | Branded Semaglutide, Branded Tirzepatide |
| Telehealth | Yes | Yes |
| Insurance | Not accepted | Accepted |
| HSA/FSA | Accepted | Accepted |
| Founded | 1889 | 2012 |
| States Served | All 50 states | 9 states |
Programs & Pricing
Mayo Clinic Diet Programs
Companion Subscription
$49.99/mo (diet support only)
- Mayo Clinic Diet Program
- Glp1 Meal Plan
- Nutrition Guidance
Clinical Subscription
$99.99/mo + $99.99 start fee + medication
Medications: Branded Semaglutide, Branded Tirzepatide, Branded Liraglutide
- Clinician Visits Via Amwell
- Mayo Clinic Diet Program
- Glp1 Meal Plan
- Nutrition Guidance
- Exercise Program
Profile by Sanford Programs
Profile Program with GLP-1
$279/mo
Medications: Branded Semaglutide, Branded Tirzepatide
- Medication
- Nutrition Coaching
- Meal Planning
- Progress Check Ins
- Health System Backing
Ratings Breakdown
| Category | Mayo Clinic Diet | Profile by Sanford |
|---|---|---|
| Overall | | |
| Value | | |
| Ease of Use | | |
| Support | | |
| Medication Quality | | |
| Results | | |
The Bottom Line
Mayo Clinic Diet edges out Profile by Sanford with a ClearScore of 78 vs 76. Mayo Clinic Diet is more affordable starting at $50/mo compared to $279/mo. For customer support, Profile by Sanford rates higher (4.5/5). The best choice depends on your priorities, medication preferences, and budget.