Profile by Sanford vs SkyRx: Prices, Programs & Reviews (2026)
Side-by-side comparison updated for 2026. ClearScores, pricing, medications, and ratings compared.
Quick Verdict
Profile by Sanford has the higher ClearScore (76 vs 75)
Profile by Sanford is more affordable ($279/mo vs $299/mo)
SkyRx has higher ratings (4.4/5 vs 4.3/5)
Profile by Sanford scores better on value (3.9/5 vs 3.6/5)
Profile by Sanford
$279/mo
starting price
Backed by Sanford Health system. Physician-designed GLP-1 programs with nutrition coaching and meal planning at clinics across the Midwest.
SkyRx
$299/mo
starting price
Premium GLP-1 program with full labs, high-touch clinician access, and both semaglutide and tirzepatide.
Profile by Sanford vs SkyRx: Full Comparison
| Profile by Sanford | SkyRx | |
|---|---|---|
| ClearScore | 76/100 ✓ | 75/100 |
| Overall Rating | 4.3/5 | 4.4/5 ✓ |
| Review Count | 157 ✓ | 58 |
| Starting Price | $279/mo ✓ | $299/mo |
| Medications | Branded Semaglutide, Branded Tirzepatide | Compounded Semaglutide, Compounded Tirzepatide |
| Telehealth | Yes | Yes |
| Insurance | Accepted | Not accepted |
| HSA/FSA | Accepted | Accepted |
| Founded | 2012 | 2022 |
| States Served | 9 states | All 50 states |
Programs & Pricing
Profile by Sanford Programs
Profile Program with GLP-1
$279/mo
Medications: Branded Semaglutide, Branded Tirzepatide
- Medication
- Nutrition Coaching
- Meal Planning
- Progress Check Ins
- Health System Backing
SkyRx Programs
Premium Weight Loss
$299/mo
Medications: Compounded Semaglutide, Compounded Tirzepatide
- Medication
- Full Labs
- Dedicated Clinician
- Priority Support
Ratings Breakdown
| Category | Profile by Sanford | SkyRx |
|---|---|---|
| Overall | | |
| Value | | |
| Ease of Use | | |
| Support | | |
| Medication Quality | | |
| Results | | |
The Bottom Line
Profile by Sanford edges out SkyRx with a ClearScore of 76 vs 75. Profile by Sanford is more affordable starting at $279/mo compared to $299/mo. For customer support, SkyRx rates higher (4.8/5). The best choice depends on your priorities, medication preferences, and budget.