Fifty 410 vs Mayo Clinic Diet: Prices, Programs & Reviews (2026)
Side-by-side comparison updated for 2026. ClearScores, pricing, medications, and ratings compared.
Fifty 410 starts at $166/mo and Mayo Clinic Diet at $50/mo. Mayo Clinic Diet scores higher on our ClearScore (68 vs 78), and Mayo Clinic Diet is the cheaper starting option.
Quick Verdict
Mayo Clinic Diet has the higher ClearScore (78 vs 68)
Mayo Clinic Diet is more affordable ($50/mo vs $166/mo)
Fifty 410 has higher ratings (4.5/5 vs 4.4/5)
Fifty 410 scores better on value (4.3/5 vs 3.8/5)
Fifty 410
$166/mo
starting price
Multi-month discounts on tirzepatide. 4.9 Trustpilot rating (2,847 reviews). Uses 503A and 503B pharmacies.
Mayo Clinic Diet
$50/mo
starting price
World-renowned Mayo Clinic's evidence-based weight loss program now includes GLP-1 prescribing with specialized meal plans for medication users.
Fifty 410 vs Mayo Clinic Diet: Full Comparison
| Fifty 410 | Mayo Clinic Diet | |
|---|---|---|
| ClearScore | 68/100 | 78/100 ✓ |
| Overall Rating | 4.5/5 ✓ | 4.4/5 |
| Review Count | 2,847 ✓ | 98 |
| Starting Price | $166/mo | $50/mo ✓ |
| Medications | Compounded Semaglutide, Compounded Tirzepatide | Branded Semaglutide, Branded Tirzepatide, Branded Liraglutide ✓ |
| Telehealth | Yes | Yes |
| Insurance | Not accepted | Not accepted |
| HSA/FSA | Accepted | Accepted |
| Founded | 2023 | 1889 |
| States Served | All 50 states | All 50 states |
Programs & Pricing
Fifty 410 Programs
Semaglutide (4 weeks)
$199/mo
Medications: Compounded Semaglutide
- Medication
- Clinician Support
- Free Shipping
Tirzepatide (4 weeks)
$299/mo
Medications: Compounded Tirzepatide
- Medication
- Clinician Support
- Free Shipping
Tirzepatide (3-month plan)
From $166/mo
Medications: Compounded Tirzepatide
- Medication
- Clinician Support
- Free Shipping
Mayo Clinic Diet Programs
Companion Subscription
$49.99/mo (diet support only)
- Mayo Clinic Diet Program
- Glp1 Meal Plan
- Nutrition Guidance
Clinical Subscription
$99.99/mo + $99.99 start fee + medication
Medications: Branded Semaglutide, Branded Tirzepatide, Branded Liraglutide
- Clinician Visits Via Amwell
- Mayo Clinic Diet Program
- Glp1 Meal Plan
- Nutrition Guidance
- Exercise Program
Ratings Breakdown
| Category | Fifty 410 | Mayo Clinic Diet |
|---|---|---|
| Overall | | |
| Value | | |
| Ease of Use | | |
| Support | | |
| Medication Quality | | |
| Results | | |
The Bottom Line
Mayo Clinic Diet edges out Fifty 410 with a ClearScore of 78 vs 68. Mayo Clinic Diet is more affordable starting at $50/mo compared to $166/mo. For customer support, Fifty 410 rates higher (4.5/5). The best choice depends on your priorities, medication preferences, and budget.