Fifty 410 vs SkyRx: Prices, Programs & Reviews (2026)
Side-by-side comparison updated for 2026. ClearScores, pricing, medications, and ratings compared.
Fifty 410 starts at $166/mo and SkyRx at $299/mo. SkyRx scores higher on our ClearScore (68 vs 75), and Fifty 410 is the cheaper starting option.
Quick Verdict
SkyRx has the higher ClearScore (75 vs 68)
Fifty 410 is more affordable ($166/mo vs $299/mo)
Fifty 410 has higher ratings (4.5/5 vs 4.4/5)
Fifty 410 scores better on value (4.3/5 vs 3.6/5)
Fifty 410
$166/mo
starting price
Multi-month discounts on tirzepatide. 4.9 Trustpilot rating (2,847 reviews). Uses 503A and 503B pharmacies.
SkyRx
$299/mo
starting price
Premium GLP-1 program with full labs, high-touch clinician access, and both semaglutide and tirzepatide.
Fifty 410 vs SkyRx: Full Comparison
| Fifty 410 | SkyRx | |
|---|---|---|
| ClearScore | 68/100 | 75/100 ✓ |
| Overall Rating | 4.5/5 ✓ | 4.4/5 |
| Review Count | 2,847 ✓ | 58 |
| Starting Price | $166/mo ✓ | $299/mo |
| Medications | Compounded Semaglutide, Compounded Tirzepatide | Compounded Semaglutide, Compounded Tirzepatide |
| Telehealth | Yes | Yes |
| Insurance | Not accepted | Not accepted |
| HSA/FSA | Accepted | Accepted |
| Founded | 2023 | 2022 |
| States Served | All 50 states | All 50 states |
Programs & Pricing
Fifty 410 Programs
Semaglutide (4 weeks)
$199/mo
Medications: Compounded Semaglutide
- Medication
- Clinician Support
- Free Shipping
Tirzepatide (4 weeks)
$299/mo
Medications: Compounded Tirzepatide
- Medication
- Clinician Support
- Free Shipping
Tirzepatide (3-month plan)
From $166/mo
Medications: Compounded Tirzepatide
- Medication
- Clinician Support
- Free Shipping
SkyRx Programs
Premium Weight Loss
$299/mo
Medications: Compounded Semaglutide, Compounded Tirzepatide
- Medication
- Full Labs
- Dedicated Clinician
- Priority Support
Ratings Breakdown
| Category | Fifty 410 | SkyRx |
|---|---|---|
| Overall | | |
| Value | | |
| Ease of Use | | |
| Support | | |
| Medication Quality | | |
| Results | | |
The Bottom Line
SkyRx edges out Fifty 410 with a ClearScore of 75 vs 68. Fifty 410 is more affordable starting at $166/mo compared to $299/mo. For customer support, SkyRx rates higher (4.8/5). The best choice depends on your priorities, medication preferences, and budget.