HormoneSynergy vs Mayo Clinic Diet: Prices, Programs & Reviews (2026)
Side-by-side comparison updated for 2026. ClearScores, pricing, medications, and ratings compared.
HormoneSynergy starts at $300/mo and Mayo Clinic Diet at $50/mo. Mayo Clinic Diet scores higher on our ClearScore (70 vs 78), and Mayo Clinic Diet is the cheaper starting option.
Quick Verdict
Mayo Clinic Diet has the higher ClearScore (78 vs 70)
Mayo Clinic Diet is more affordable ($50/mo vs $300/mo)
HormoneSynergy has higher ratings (4.6/5 vs 4.4/5)
HormoneSynergy scores better on value (4.1/5 vs 3.8/5)
HormoneSynergy
$300/mo
starting price
Longevity-focused GLP-1 program with DEXA scans, CGM, and hormone optimization in Portland, OR.
Mayo Clinic Diet
$50/mo
starting price
World-renowned Mayo Clinic's evidence-based weight loss program now includes GLP-1 prescribing with specialized meal plans for medication users.
HormoneSynergy vs Mayo Clinic Diet: Full Comparison
| HormoneSynergy | Mayo Clinic Diet | |
|---|---|---|
| ClearScore | 70/100 | 78/100 ✓ |
| Overall Rating | 4.6/5 ✓ | 4.4/5 |
| Review Count | 42 | 98 ✓ |
| Starting Price | $300/mo | $50/mo ✓ |
| Medications | Semaglutide, Tirzepatide | Branded Semaglutide, Branded Tirzepatide, Branded Liraglutide ✓ |
| Telehealth | No | Yes |
| Insurance | Not accepted | Not accepted |
| HSA/FSA | Not accepted | Accepted |
| Founded | 2006 | 1889 |
| States Served | 1 states | All 50 states |
Programs & Pricing
HormoneSynergy Programs
Weight Loss for Longevity
From $300/mo
Medications: Semaglutide, Tirzepatide
- Medication
- Dexa Scans
- Cgm Monitoring
- Hormone Optimization
Mayo Clinic Diet Programs
Companion Subscription
$49.99/mo (diet support only)
- Mayo Clinic Diet Program
- Glp1 Meal Plan
- Nutrition Guidance
Clinical Subscription
$99.99/mo + $99.99 start fee + medication
Medications: Branded Semaglutide, Branded Tirzepatide, Branded Liraglutide
- Clinician Visits Via Amwell
- Mayo Clinic Diet Program
- Glp1 Meal Plan
- Nutrition Guidance
- Exercise Program
Ratings Breakdown
| Category | HormoneSynergy | Mayo Clinic Diet |
|---|---|---|
| Overall | | |
| Value | | |
| Ease of Use | | |
| Support | | |
| Medication Quality | | |
| Results | | |
The Bottom Line
Mayo Clinic Diet edges out HormoneSynergy with a ClearScore of 78 vs 70. Mayo Clinic Diet is more affordable starting at $50/mo compared to $300/mo. For customer support, HormoneSynergy rates higher (4.7/5). The best choice depends on your priorities, medication preferences, and budget.