Mayo Clinic Diet vs Sesame: Prices, Programs & Reviews (2026)
Side-by-side comparison updated for 2026. ClearScores, pricing, medications, and ratings compared.
Mayo Clinic Diet starts at $50/mo and Sesame at $99/mo. Mayo Clinic Diet scores higher on our ClearScore (78 vs 74), and Mayo Clinic Diet is the cheaper starting option.
Quick Verdict
Mayo Clinic Diet has the higher ClearScore (78 vs 74)
Mayo Clinic Diet is more affordable ($50/mo vs $99/mo)
Mayo Clinic Diet has higher ratings (4.4/5 vs 4.1/5)
Sesame scores better on value (4.3/5 vs 3.8/5)
Mayo Clinic Diet
$50/mo
starting price
World-renowned Mayo Clinic's evidence-based weight loss program now includes GLP-1 prescribing with specialized meal plans for medication users.
Sesame
$99/mo
starting price
Wide medication selection with 14 options, insurance navigation support, and same-day consultations starting at $99/month.
Mayo Clinic Diet vs Sesame: Full Comparison
| Mayo Clinic Diet | Sesame | |
|---|---|---|
| ClearScore | 78/100 ✓ | 74/100 |
| Overall Rating | 4.4/5 ✓ | 4.1/5 |
| Review Count | 98 | 156 ✓ |
| Starting Price | $50/mo ✓ | $99/mo |
| Medications | Branded Semaglutide, Branded Tirzepatide, Branded Liraglutide | Branded Semaglutide, Branded Tirzepatide, Branded Liraglutide, Metformin, Contrave ✓ |
| Telehealth | Yes | Yes |
| Insurance | Not accepted | Accepted |
| HSA/FSA | Accepted | Accepted |
| Founded | 1889 | 2018 |
| States Served | All 50 states | All 50 states |
Programs & Pricing
Mayo Clinic Diet Programs
Companion Subscription
$49.99/mo (diet support only)
- Mayo Clinic Diet Program
- Glp1 Meal Plan
- Nutrition Guidance
Clinical Subscription
$99.99/mo + $99.99 start fee + medication
Medications: Branded Semaglutide, Branded Tirzepatide, Branded Liraglutide
- Clinician Visits Via Amwell
- Mayo Clinic Diet Program
- Glp1 Meal Plan
- Nutrition Guidance
- Exercise Program
Sesame Programs
Success by Sesame
$99/mo + medication
Medications: Branded Semaglutide, Branded Tirzepatide, Branded Liraglutide
- Clinician Consultations
- Labs Included
- Insurance Navigation
- Same Day Appointments
Ratings Breakdown
| Category | Mayo Clinic Diet | Sesame |
|---|---|---|
| Overall | | |
| Value | | |
| Ease of Use | | |
| Support | | |
| Medication Quality | | |
| Results | | |
The Bottom Line
Mayo Clinic Diet edges out Sesame with a ClearScore of 78 vs 74. Mayo Clinic Diet is more affordable starting at $50/mo compared to $99/mo. For customer support, Mayo Clinic Diet rates higher (4.3/5). The best choice depends on your priorities, medication preferences, and budget.