Sesame vs SkyRx: Prices, Programs & Reviews (2026)
Side-by-side comparison updated for 2026. ClearScores, pricing, medications, and ratings compared.
Sesame starts at $99/mo and SkyRx at $299/mo. SkyRx scores higher on our ClearScore (74 vs 75), and Sesame is the cheaper starting option.
Quick Verdict
SkyRx has the higher ClearScore (75 vs 74)
Sesame is more affordable ($99/mo vs $299/mo)
SkyRx has higher ratings (4.4/5 vs 4.1/5)
Sesame scores better on value (4.3/5 vs 3.6/5)
Sesame
$99/mo
starting price
Wide medication selection with 14 options, insurance navigation support, and same-day consultations starting at $99/month.
SkyRx
$299/mo
starting price
Premium GLP-1 program with full labs, high-touch clinician access, and both semaglutide and tirzepatide.
Sesame vs SkyRx: Full Comparison
| Sesame | SkyRx | |
|---|---|---|
| ClearScore | 74/100 | 75/100 ✓ |
| Overall Rating | 4.1/5 | 4.4/5 ✓ |
| Review Count | 156 ✓ | 58 |
| Starting Price | $99/mo ✓ | $299/mo |
| Medications | Branded Semaglutide, Branded Tirzepatide, Branded Liraglutide, Metformin, Contrave ✓ | Compounded Semaglutide, Compounded Tirzepatide |
| Telehealth | Yes | Yes |
| Insurance | Accepted | Not accepted |
| HSA/FSA | Accepted | Accepted |
| Founded | 2018 | 2022 |
| States Served | All 50 states | All 50 states |
Programs & Pricing
Sesame Programs
Success by Sesame
$99/mo + medication
Medications: Branded Semaglutide, Branded Tirzepatide, Branded Liraglutide
- Clinician Consultations
- Labs Included
- Insurance Navigation
- Same Day Appointments
SkyRx Programs
Premium Weight Loss
$299/mo
Medications: Compounded Semaglutide, Compounded Tirzepatide
- Medication
- Full Labs
- Dedicated Clinician
- Priority Support
Ratings Breakdown
| Category | Sesame | SkyRx |
|---|---|---|
| Overall | | |
| Value | | |
| Ease of Use | | |
| Support | | |
| Medication Quality | | |
| Results | | |
The Bottom Line
SkyRx edges out Sesame with a ClearScore of 75 vs 74. Sesame is more affordable starting at $99/mo compared to $299/mo. For customer support, SkyRx rates higher (4.8/5). The best choice depends on your priorities, medication preferences, and budget.